Ontology highlight
ABSTRACT:
SUBMITTER: Shao W
PROVIDER: S-EPMC4810322 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Shao Wenwei W Zhang Chi C Liu Enyang E Zhang Long L Ma Junfan J Zhu Zhu Z Gong Xiaoting X Qin Zhihai Z Qiu Xiaoyan X
Scientific reports 20160329
Growing evidence indicates that B cells are not the only source of immunoglobulin (Ig). To investigate this discovery further, we used μMT mice, which have a disruption of the first transmembrane exon of the μ heavy chain and do not express the membrane form of IgM. These mice lack mature B cells and thus serve as a good model to explore Ig expression by liver epithelial cells. We found that Ig heavy chains (μ, δ, γ and α) and light chains (κ and λ) were expressed in sorted liver epithelial cell ...[more]