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Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.

ABSTRACT: We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

SUBMITTER: Yang XL

PROVIDER: S-EPMC4810638 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.

Yang Xing-Lou XL Hu Ben B Wang Bo B Wang Mei-Niang MN Zhang Qian Q Zhang Wei W Wu Li-Jun LJ Ge Xing-Yi XY Zhang Yun-Zhi YZ Daszak Peter P Wang Lin-Fa LF Shi Zheng-Li ZL

Journal of virology 20151230 6

We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emerg ...[more]

PMID: 26719272

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