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Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.

ABSTRACT: We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emergence in humans.

SUBMITTER: Yang XL 

PROVIDER: S-EPMC4810638 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus.

Yang Xing-Lou XL   Hu Ben B   Wang Bo B   Wang Mei-Niang MN   Zhang Qian Q   Zhang Wei W   Wu Li-Jun LJ   Ge Xing-Yi XY   Zhang Yun-Zhi YZ   Daszak Peter P   Wang Lin-Fa LF   Shi Zheng-Li ZL  

Journal of virology 20151230 6

We report the isolation and characterization of a novel bat coronavirus which is much closer to the severe acute respiratory syndrome coronavirus (SARS-CoV) in genomic sequence than others previously reported, particularly in its S gene. Cell entry and susceptibility studies indicated that this virus can use ACE2 as a receptor and infect animal and human cell lines. Our results provide further evidence of the bat origin of the SARS-CoV and highlight the likelihood of future bat coronavirus emerg  ...[more]

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