Ontology highlight
ABSTRACT:
SUBMITTER: Lee D
PROVIDER: S-EPMC4811118 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lee Dongjun D Wang Ying-Hua YH Kalaitzidis Demetrios D Ramachandran Janani J Eda Homare H Sykes David B DB Raje Noopur N Scadden David T DT
The Journal of clinical investigation 20160229 4
Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation of STAT3. Specifically, we determined that UT2 interacts directly with GP130 and inhibits phosphorylation of STAT3 on tyrosine 705 (STAT3Y705). This reduces cytokine signaling including IL6 that is implicated in multiple myeloma and other hematopoietic malignancies. Modulatio ...[more]