Ontology highlight
ABSTRACT:
SUBMITTER: Soucie EL
PROVIDER: S-EPMC4811353 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160121 6274
Differentiated macrophages can self-renew in tissues and expand long term in culture, but the gene regulatory mechanisms that accomplish self-renewal in the differentiated state have remained unknown. Here we show that in mice, the transcription factors MafB and c-Maf repress a macrophage-specific enhancer repertoire associated with a gene network that controls self-renewal. Single-cell analysis revealed that, in vivo, proliferating resident macrophages can access this network by transient down- ...[more]