Unknown

Dataset Information

0

Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds.


ABSTRACT: Knowledge of pharmacokinetic/pharmacodynamic (PK/PD) relationships can enhance the speed and economy of drug development by enabling informed and rational decisions at every step, from lead selection to clinical dosing. For anti-infective agents in particular, dynamic in vitro hollow-fiber cartridge experiments permit exquisite control of kinetic parameters and the study of their consequent impact on pharmacodynamic efficacy. Such information is of great interest for the cost-restricted but much-needed development of new antimalarial drugs, especially since the major human pathogen Plasmodium falciparum can be cultivated in vitro but is not readily available in animal models. This protocol describes the materials and procedures for determining the PK/PD relationships of antimalarial compounds.

SUBMITTER: Caton E 

PROVIDER: S-EPMC4811375 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds.

Caton Emily E   Nenortas Elizabeth E   Bakshi Rahul P RP   Shapiro Theresa A TA  

Current protocols in chemical biology 20160316 1


Knowledge of pharmacokinetic/pharmacodynamic (PK/PD) relationships can enhance the speed and economy of drug development by enabling informed and rational decisions at every step, from lead selection to clinical dosing. For anti-infective agents in particular, dynamic in vitro hollow-fiber cartridge experiments permit exquisite control of kinetic parameters and the study of their consequent impact on pharmacodynamic efficacy. Such information is of great interest for the cost-restricted but much  ...[more]

Similar Datasets

| S-EPMC8589829 | biostudies-literature
| S-EPMC5923117 | biostudies-literature
| S-EPMC4011360 | biostudies-other
| S-EPMC7318083 | biostudies-literature
| S-EPMC3837908 | biostudies-literature
| S-EPMC7993277 | biostudies-literature
| S-EPMC5729907 | biostudies-literature
| S-EPMC3715401 | biostudies-literature
| S-EPMC10728507 | biostudies-literature