Ontology highlight
ABSTRACT:
SUBMITTER: Wang HX
PROVIDER: S-EPMC4811443 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Wang Hong-Xia HX Qiu Yu-Rong YR Zhong Xiao-Ping XP
PloS one 20160329 3
Promiscuous expression of tissue restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs) is crucial for negative selection of self-reactive T cells to establish central tolerance. Intercellular transfer of self-peptide-MHC complexes from mTECs to thymic dendritic cells (DCs) allows DCs to acquire TRAs, which in turn contributes to negative selection and regulatory T cell generation. However, mTECs are unlikely to express all TRAs, such as immunoglobulins generated only in B cells ...[more]