Ontology highlight
ABSTRACT:
SUBMITTER: Bersani C
PROVIDER: S-EPMC4811505 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Bersani Cinzia C Huss Mikael M Giacomello Stefania S Xu Li-Di LD Bianchi Julie J Eriksson Sofi S Jerhammar Fredrik F Alexeyenko Andrey A Vilborg Anna A Lundeberg Joakim J Lui Weng-Onn WO Wiman Klas G KG
Oncotarget 20160101 2
RNA-binding proteins (RBPs) play important roles in the regulation of gene expression through a variety of post-transcriptional mechanisms. The p53-induced RBP Wig-1 (Zmat3) binds RNA through its zinc finger domains and enhances stability of p53 and N-Myc mRNAs and decreases stability of FAS mRNA. To identify novel Wig-1-bound RNAs, we performed RNA-immunoprecipitation followed by high-throughput sequencing (RIP-Seq) in HCT116 and Saos-2 cells. We identified 286 Wig-1-bound mRNAs common between ...[more]