Ontology highlight
ABSTRACT:
SUBMITTER: Duarte-Pereira S
PROVIDER: S-EPMC4811510 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Duarte-Pereira Sara S Pereira-Castro Isabel I Silva Sarah S SS Correia Mariana Gonçalves MG Neto Célia C da Costa Luís Teixeira LT Amorim António A Silva Raquel M RM
Oncotarget 20160101 2
Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs and sirtuins. As cancer cells have increased NAD requirements, the main NAD salvage enzymes in humans, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosphoribosyltransferase (NAPRT), are involved in the development of novel anti-cancer therapies. Knowledge of the expression patterns of both genes in tissues and tumors is critical for the use of nicoti ...[more]