Ontology highlight
ABSTRACT:
SUBMITTER: Marziale AN
PROVIDER: S-EPMC4811629 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Advanced synthesis & catalysis 20150714 10
Enantioselective catalytic allylic alkylation for the synthesis of 2-alkyl-2-allylcycloalkanones and 3,3-disubstituted pyrrolidinones, piperidinones and piperazinones has been previously reported by our laboratory. The efficient construction of chiral all-carbon quaternary centers by allylic alkylation was previously achieved with a catalyst derived <i>in situ</i> from zero valent palladium sources and chiral phosphinooxazoline (PHOX) ligands. We now report an improved reaction protocol with bro ...[more]