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Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses.

ABSTRACT: Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and reinfect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA), and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies. Here, we show that antigenic differences measured through serological assay data are well described by a sum of antigenic changes along the path connecting viruses in a phylogenetic tree. This mapping onto the tree allows prediction of antigenicity from HA sequence data alone. The mapping can further be used to make predictions about the makeup of the future A(H3N2) seasonal influenza virus population, and we compare predictions between models with serological and sequence data. To make timely model output readily available, we developed a web browser-based application that visualizes antigenic data on a continuously updated phylogeny.

SUBMITTER: Neher RA

PROVIDER: S-EPMC4812706 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses.

Neher Richard A RA Bedford Trevor T Daniels Rodney S RS Russell Colin A CA Shraiman Boris I BI

Proceedings of the National Academy of Sciences of the United States of America 20160307 12

Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and reinfect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA), and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies. Here, we show that antigenic differences measured through serological assay data are well described by a sum of antigenic changes along the path connecting viruse ...[more]

PMID: 26951657

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Dataset Information

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses.

Publications

Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses.

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