Ontology highlight
ABSTRACT:
SUBMITTER: Smith CA
PROVIDER: S-EPMC4812760 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Smith Colin A CA Ban David D Pratihar Supriya S Giller Karin K Paulat Maria M Becker Stefan S Griesinger Christian C Lee Donghan D de Groot Bert L BL
Proceedings of the National Academy of Sciences of the United States of America 20160309 12
Many biological processes depend on allosteric communication between different parts of a protein, but the role of internal protein motion in propagating signals through the structure remains largely unknown. Through an experimental and computational analysis of the ground state dynamics in ubiquitin, we identify a collective global motion that is specifically linked to a conformational switch distant from the binding interface. This allosteric coupling is also present in crystal structures and ...[more]