Ontology highlight
ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC4813181 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Yan Xinmiao X Kang Hong H Feng Jun J Yang Yiyan Y Tang Kailin K Zhu Ruixin R Yang Li L Wang Zhengtao Z Cao Zhiwei Z
International journal of molecular sciences 20160307 3
Pyrrolizidine Alkaloids (PAs) are currently one of the most important botanical hepatotoxic ingredients. Glutathion (GSH) metabolism is the most reported pathway involved in hepatotoxicity mechanism of PAs. We speculate that, for different PAs, there should be a common mechanism underlying their hepatotoxicity in GSH metabolism. Computational methods were adopted to test our hypothesis in consideration of the limitations of current experimental approaches. Firstly, the potential targets of 22 PA ...[more]