Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC4813245 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Wang Xing X Zhang Yuxin Y Liu Qing Q Ai Zhixin Z Zhang Yanling Y Xiang Yuhong Y Qiao Yanjiang Y
International journal of molecular sciences 20160316 3
Endothelin-1 receptors (ETAR and ETBR) act as a pivotal regulator in the biological effects of ET-1 and represent a potential drug target for the treatment of multiple cardiovascular diseases. The purpose of the study is to discover dual ETA/ETB receptor antagonists from traditional Chinese herbs. Ligand- and structure-based virtual screening was performed to screen an in-house database of traditional Chinese herbs, followed by a series of in vitro bioassay evaluation. Aristolochic acid A (AAA) ...[more]