Ontology highlight
ABSTRACT:
SUBMITTER: Ding ZY
PROVIDER: S-EPMC4813263 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ding Ze-Yang ZY Jin Guan-Nan GN Wang Wei W Sun Yi-Min YM Chen Wei-Xun WX Chen Lin L Liang Hui-Fang HF Datta Pran K PK Zhang Ming-Zhi MZ Zhang Bixiang B Chen Xiao-Ping XP
International journal of molecular sciences 20160322 3
Liver progenitor cells (LPCs) are activated in chronic liver damage and may contribute to liver fibrosis. Our previous investigation reported that LPCs produced connective tissue growth factor (CTGF/CCN2), an inducer of liver fibrosis, yet the regulatory mechanism of the production of CTGF/CCN2 in LPCs remains elusive. In this study, we report that Activin A is an inducer of CTGF/CCN2 in LPCs. Here we show that expression of both Activin A and CTGF/CCN2 were upregulated in the cirrhotic liver, a ...[more]