Ontology highlight
ABSTRACT:
SUBMITTER: Munst B
PROVIDER: S-EPMC4813312 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Münst Bernhard B Thier Marc Christian MC Winnemöller Dirk D Helfen Martina M Thummer Rajkumar P RP Edenhofer Frank F
Journal of cell science 20160121 5
A comprehensive analysis of the molecular network of cellular factors establishing and maintaining pluripotency as well as self renewal of pluripotent stem cells is key for further progress in understanding basic stem cell biology. Nanog is necessary for the natural induction of pluripotency in early mammalian development but dispensable for both its maintenance and its artificial induction. To gain further insight into the molecular activity of Nanog, we analyzed the outcomes of Nanog gain-of-f ...[more]