Ontology highlight
ABSTRACT:
SUBMITTER: Salerno JC
PROVIDER: S-EPMC4813321 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Salerno John C JC Ngwa Verra M VM Nowak Scott J SJ Chrestensen Carol A CA Healey Allison N AN McMurry Jonathan L JL
Journal of cell science 20160122 5
The use of cell-penetrating peptides (CPPs) as biomolecular delivery vehicles holds great promise for therapeutic and other applications, but development has been stymied by poor delivery and lack of endosomal escape. We have developed a CPP-adaptor system capable of efficient intracellular delivery and endosomal escape of user-defined protein cargos. The cell-penetrating sequence of HIV transactivator of transcription was fused to calmodulin, which binds with subnanomolar affinity to proteins c ...[more]