Ontology highlight
ABSTRACT:
SUBMITTER: Selimkhanov J
PROVIDER: S-EPMC4813785 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Selimkhanov Jangir J Taylor Brooks B Yao Jason J Pilko Anna A Albeck John J Hoffmann Alexander A Tsimring Lev L Wollman Roy R
Science (New York, N.Y.) 20141201 6215
Stochasticity inherent to biochemical reactions (intrinsic noise) and variability in cellular states (extrinsic noise) degrade information transmitted through signaling networks. We analyzed the ability of temporal signal modulation--that is, dynamics--to reduce noise-induced information loss. In the extracellular signal-regulated kinase (ERK), calcium (Ca(2+)), and nuclear factor kappa-B (NF-κB) pathways, response dynamics resulted in significantly greater information transmission capacities co ...[more]