Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.
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ABSTRACT:
SUBMITTER: Munster VJ
PROVIDER: S-EPMC4814155 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.
Munster Vincent J VJ de Wit Emmie E van den Brand Judith M A JM Herfst Sander S Schrauwen Eefje J A EJ Bestebroer Theo M TM van de Vijver David D Boucher Charles A CA Koopmans Marion M Rimmelzwaan Guus F GF Kuiken Thijs T Osterhaus Albert D M E AD Fouchier Ron A M RA
Science (New York, N.Y.) 20090702 5939
The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea ...[more]
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