Ontology highlight
ABSTRACT:
SUBMITTER: Wan X
PROVIDER: S-EPMC4814174 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Wan Xiaoyang X Chen Zhaohong Z Choi Won-Il WI Gee Heon Yung HY Hildebrandt Friedhelm F Zhou Weibin W
Journal of the American Society of Nephrology : JASN 20150811 4
Nephrotic syndrome is a CKD defined by proteinuria with subsequent hypoalbuminemia, hyperlipidemia, and edema caused by impaired renal glomerular filtration barrier function. We previously identified mutations in epithelial membrane protein 2 (EMP2) as a monogenic cause of this disease. Here, we generated an emp2-knockout zebrafish model using transcription activator-like effector nuclease-based genome editing. We found that loss of emp2 in zebrafish upregulated caveolin-1 (cav1), a major compon ...[more]