Ontology highlight
ABSTRACT:
SUBMITTER: Gagliardini E
PROVIDER: S-EPMC4814190 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Gagliardini Elena E Novelli Rubina R Corna Daniela D Zoja Carlamaria C Ruggiero Barbara B Benigni Ariela A Remuzzi Giuseppe G
Journal of the American Society of Nephrology : JASN 20150828 4
The incidence of progressive kidney disease associated with diabetes continues to rise worldwide. Current standard therapy with angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers achieves only partial renoprotection, increasing the need for novel therapeutic approaches. Previous studies described B7-1 induction in podocytes of patients with proteinuria, including those with FSGS and type 2 diabetic nephropathy (DN). These findings sparked great excitement in the renal ...[more]