Ontology highlight
ABSTRACT:
SUBMITTER: Newhart A
PROVIDER: S-EPMC4814222 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Newhart Alyshia A Powers Sara Lawrence SL Shastrula Prashanth Krishna PK Sierra Isabel I Joo Lucy M LM Hayden James E JE Cohen Andrew R AR Janicki Susan M SM
Molecular biology of the cell 20160203 7
In mammals, histone H3.3 is a critical regulator of transcription state change and heritability at both euchromatin and heterochromatin. The H3.3-specific chaperone, DAXX, together with the chromatin-remodeling factor, ATRX, regulates H3.3 deposition and transcriptional silencing at repetitive DNA, including pericentromeres and telomeres. However, the events that precede H3.3 nucleosome incorporation have not been fully elucidated. We previously showed that the DAXX-ATRX-H3.3 pathway regulates a ...[more]