Ontology highlight
ABSTRACT:
SUBMITTER: Bolin K
PROVIDER: S-EPMC4814314 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Bolin Kelsey K Rachmaninoff Nicholas N Moncada Kea K Pula Katharine K Kennell Jennifer J Buttitta Laura L
Developmental biology 20160221 1
The miR-200 microRNA family plays important tumor suppressive roles. The sole Drosophila miR-200 ortholog, miR-8 plays conserved roles in Wingless, Notch and Insulin signaling - pathways linked to tumorigenesis, yet homozygous null animals are viable and often appear morphologically normal. We observed that wing tissues mosaic for miR-8 levels by genetic loss or gain of function exhibited patterns of cell death consistent with a role for miR-8 in modulating cell survival in vivo. Here we show th ...[more]