Ontology highlight
ABSTRACT:
SUBMITTER: Lo PK
PROVIDER: S-EPMC4814335 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Lo Pang-Kuo PK Huang Yi-Chun YC Poulton John S JS Leake Nicholas N Palmer William H WH Vera Daniel D Xie Gengqiang G Klusza Stephen S Deng Wu-Min WM
Developmental biology 20160218 1
Belle (Bel), the Drosophila homolog of the yeast DEAD-box RNA helicase DED1 and human DDX3, has been shown to be required for oogenesis and female fertility. Here we report a novel role of Bel in regulating the expression of transgenes. Abrogation of Bel by mutations or RNAi induces silencing of a variety of P-element-derived transgenes. This silencing effect depends on downregulation of their RNA levels. Our genetic studies have revealed that the RNA helicase Spindle-E (Spn-E), a nuage RNA heli ...[more]