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ABSTRACT: Background
The social stigma and chronicity of psoriasis significantly affect health-related quality of life (HRQoL).Objective
We examined the effect of three regimens of secukinumab on HRQoL in moderate to severe psoriasis patients.Methods
Twelve-week data from a phase II, randomized, double-blind, placebo-controlled, regimen-finding study evaluated HRQoL, measured by the Dermatology Life Quality Index (DLQI). Secukinumab or placebo was administered subcutaneously in three treatment regimens: single (baseline only), monthly (baseline, weeks 4, 8) and early (baseline, weeks 1, 2, 4). Differences among regimens were assessed with logistic regression models and Fisher's exact test.Results
Patients (n = 404) were randomized to single (baseline) treatment regimen, n = 66; monthly, (baseline, weeks 4 and 8), n = 138; early, (baseline, weeks 1, 2, 4), n = 133; and placebo, n = 67. DLQI response was significantly higher in early, monthly and single regimens than in placebo regimen (40.8%, 33.6% and 13.1% vs. 1.6%, respectively; P < 0.001 for all).Conclusion
Moderate to severe psoriasis patients receiving monthly and early treatment with secukinumab demonstrated improved HRQoL compared with placebo.
SUBMITTER: Augustin M
PROVIDER: S-EPMC4814339 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Augustin M M Abeysinghe S S Mallya U U Qureshi A A Roskell N N McBride D D Papavassillis C C Gelfand J J
Journal of the European Academy of Dermatology and Venereology : JEADV 20151210 4
<h4>Background</h4>The social stigma and chronicity of psoriasis significantly affect health-related quality of life (HRQoL).<h4>Objective</h4>We examined the effect of three regimens of secukinumab on HRQoL in moderate to severe psoriasis patients.<h4>Methods</h4>Twelve-week data from a phase II, randomized, double-blind, placebo-controlled, regimen-finding study evaluated HRQoL, measured by the Dermatology Life Quality Index (DLQI). Secukinumab or placebo was administered subcutaneously in thr ...[more]