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Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

ABSTRACT: Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N?=?1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n?=?942) revealed genome-wide significant results in or near the APOH gene on chromosome 17 (top SNP, rs7211380, p?=?1?×?10(-11)). The results were replicated in an independent cohort, the Hunter Community Study (p?

SUBMITTER: Mather KA

PROVIDER: S-EPMC4814826 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

Mather Karen A KA Thalamuthu Anbupalam A Oldmeadow Christopher C Song Fei F Armstrong Nicola J NJ Poljak Anne A Holliday Elizabeth G EG McEvoy Mark M Kwok John B JB Assareh Amelia A AA Reppermund Simone S Kochan Nicole A NA Lee Teresa T Ames David D Wright Margaret J MJ Trollor Julian N JN Schofield Peter W PW Brodaty Henry H Scott Rodney J RJ Schofield Peter R PR Attia John R JR Sachdev Perminder S PS

Scientific reports 20160331

Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N = 1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n = 942) revealed genome-wide ...[more]

PMID: 27030319

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Project description:BackgroundBiomarkers that allow detection of the onset of disease are of high interest since early detection would allow intervening with lifestyle and nutritional changes before the disease is manifested and pharmacological therapy is required. Our study aimed to improve the phenotypic characterization of overweight but apparently healthy subjects and to identify new candidate profiles for early biomarkers of obesity-related diseases such as cardiovascular disease and type 2 diabetes.Methodology/principal findingsIn a population of 56 healthy, middle-aged overweight subjects Body Mass Index (BMI), fasting concentration of 124 plasma proteins and insulin were determined. The plasma proteins are implicated in chronic diseases, inflammation, endothelial function and metabolic signaling. Random Forest was applied to select proteins associated with BMI and plasma insulin. Subsequently, the selected proteins were analyzed by clustering methods to identify protein clusters associated with BMI and plasma insulin. Similar analyses were performed for a second population of 20 healthy, overweight older subjects to verify associations found in population I. In both populations similar clusters of proteins associated with BMI or insulin were identified. Leptin and a number of pro-inflammatory proteins, previously identified as possible biomarkers for obesity-related disease, e.g. Complement 3, C Reactive Protein, Serum Amyloid P, Vascular Endothelial Growth Factor clustered together and were positively associated with BMI and insulin. IL-3 and IL-13 clustered together with Apolipoprotein A1 and were inversely associated with BMI and might be potential new biomarkers. CONCLUSION/ SIGNIFICANCE: We identified clusters of plasma proteins associated with BMI and insulin in healthy populations. These clusters included previously reported biomarkers for obesity-related disease and potential new biomarkers such as IL-3 and IL-13. These plasma protein clusters could have potential applications for improved phenotypic characterization of volunteers in nutritional intervention studies or as biomarkers in the early detection of obesity-linked disease development and progression.

Dataset Information

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

Publications

Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

Similar Datasets

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