Ontology highlight
ABSTRACT:
SUBMITTER: Zhang CE
PROVIDER: S-EPMC4814850 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Zhang Cong-En CE Niu Ming M Li Rui-Yu RY Feng Wu-Wen WW Ma Xiao X Dong Qin Q Ma Zhi-Jie ZJ Li Guang-Quan GQ Meng Ya-Kun YK Wang Ya Y Yin Ping P He Lan-Zhi LZ Li Yu-Meng YM Tan Peng P Zhao Yan-Ling YL Wang Jia-Bo JB Dong Xiao-Ping XP Xiao Xiao-He XH
Frontiers in pharmacology 20160331
Cholestasis is a serious manifestation of liver diseases with limited therapies. Rhubarb, a widely used herbal medicine, has been frequently used at a relatively large dose for treating cholestasis. However, whether large doses are optimal and the therapeutic mechanism remain unclear. To explore these questions, the anti-cholestatic effect of five doses of rhubarb (0.21, 0.66, 2.10, 6.60, and 21.0 g/kg) in an alpha-naphthylisothiocyanate (ANIT)-induced rat model of cholestasis was examined by hi ...[more]