Ontology highlight
ABSTRACT:
SUBMITTER: Gupta S
PROVIDER: S-EPMC4814902 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Gupta Sudheer S Chaudhary Kumardeep K Kumar Rahul R Gautam Ankur A Nanda Jagpreet Singh JS Dhanda Sandeep Kumar SK Brahmachari Samir Kumar SK Raghava Gajendra P S GP
Scientific reports 20160331
In this study, we investigated drug profile of 24 anticancer drugs tested against a large number of cell lines in order to understand the relation between drug resistance and altered genomic features of a cancer cell line. We detected frequent mutations, high expression and high copy number variations of certain genes in both drug resistant cell lines and sensitive cell lines. It was observed that a few drugs, like Panobinostat, are effective against almost all types of cell lines, whereas certa ...[more]