Ontology highlight
ABSTRACT: Background
The automated reconstruction of genome sequences in ancient genome analysis is a multifaceted process.Results
Here we introduce EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets. EAGER provides features to preprocess, map, authenticate, and assess the quality of ancient DNA samples. Additionally, EAGER comprises tools to genotype samples to discover, filter, and analyze variants.Conclusions
EAGER encompasses both state-of-the-art tools for each step as well as new complementary tools tailored for ancient DNA data within a single integrated solution in an easily accessible format.
SUBMITTER: Peltzer A
PROVIDER: S-EPMC4815194 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Peltzer Alexander A Jäger Günter G Herbig Alexander A Seitz Alexander A Kniep Christian C Krause Johannes J Nieselt Kay K
Genome biology 20160331
<h4>Background</h4>The automated reconstruction of genome sequences in ancient genome analysis is a multifaceted process.<h4>Results</h4>Here we introduce EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets. EAGER provides features to preprocess, map, authenticate, and assess the quality of ancient DNA samples. Additionally, EAGER comprises tools to genotype samples to discover, filter, and analyze variants.<h4>Conclusions</h4>EAGER encompasse ...[more]