Comprehensive analysis of sequences of a protein switch.
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ABSTRACT:
SUBMITTER: Chen SH
PROVIDER: S-EPMC4815306 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Comprehensive analysis of sequences of a protein switch.
Chen Szu-Hua SH Meller Jaroslaw J Elber Ron R
Protein science : a publication of the Protein Society 20150701 1
Switches form a special class of proteins that dramatically change their three-dimensional structures upon a small perturbation. One possible perturbation that we explore is that of a single point mutation. Building on the pioneering experimental work of Alexander et al. (Alexander et al. PNAS, 2007; 104,11963-11968) that determines switch sequences between α and α+β folds we conduct a comprehensive sequence sampling by a Markov Chain with multiple fitness criteria to identify new switches given ...[more]
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