Ontology highlight
ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC4815351 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20151125 2
Retroviral DNA integration is mediated by nucleoprotein complexes (intasomes) comprising a pair of viral DNA ends synapsed by a tetramer of integrase. Current integrase inhibitors act on intasomes rather than free integrase protein. Structural and functional studies of intasomes are essential to understand their mechanism of action and how the virus can escape by mutation. To date, prototype foamy virus (PFV) is the only retrovirus for which high-resolution structures of intasomes have been dete ...[more]