Ontology highlight
ABSTRACT:
SUBMITTER: Kong X
PROVIDER: S-EPMC4815426 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Kong Xiangxing X Su Fengyu F Zhang Liqiang L Yaron Jordan J Lee Fred F Shi Zhengwei Z Tian Yanqing Y Meldrum Deirdre R DR
Angewandte Chemie (International ed. in English) 20150821 41
Regulation of intracellular potassium (K(+) ) concentration plays a key role in metabolic processes. So far, only a few intracellular K(+) sensors have been developed. The highly selective fluorescent K(+) sensor KS6 for monitoring K(+) ion dynamics in mitochondria was produced by coupling triphenylphosphonium, borondipyrromethene (BODIPY), and triazacryptand (TAC). KS6 shows a good response to K(+) in the range 30-500 mM, a large dynamic range (Fmax /F0 ≈130), high brightness (ϕf =14.4 % at 150 ...[more]