Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC4816147 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Liu Dong D Liu Xing X Zhou Ti T Yao William W Zhao Jun J Zheng Zhigang Z Jiang Wei W Wang Fengsong F Aikhionbare Felix O FO Hill Donald L DL Emmett Nerimah N Guo Zhen Z Wang Dongmei D Yao Xuebiao X Chen Yong Y
Journal of molecular cell biology 20151228 2
Endoplasmic reticulum (ER) stress is involved in ischemic preconditioning that protects various organs from ischemia/reperfusion (I/R) injury. We established an in vivo ER stress preconditioning model in which tunicamycin was injected into rats before hepatic I/R. The hepatic I/R injury, demonstrated by serum aminotransferase level and the ultra-structure of the liver, was alleviated by administration of tunicamycin, which induced ER stress in rat liver by activating inositol-requiring enzyme 1 ...[more]