Prediction of disease-gene-drug relationships following a differential network analysis.
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ABSTRACT:
SUBMITTER: Zickenrott S
PROVIDER: S-EPMC4816176 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
Prediction of disease-gene-drug relationships following a differential network analysis.
Zickenrott S S Angarica V E VE Upadhyaya B B BB del Sol A A
Cell death & disease 20160114
Great efforts are being devoted to get a deeper understanding of disease-related dysregulations, which is central for introducing novel and more effective therapeutics in the clinics. However, most human diseases are highly multifactorial at the molecular level, involving dysregulation of multiple genes and interactions in gene regulatory networks. This issue hinders the elucidation of disease mechanism, including the identification of disease-causing genes and regulatory interactions. Most of c ...[more]
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