Ontology highlight
ABSTRACT:
SUBMITTER: Huang W
PROVIDER: S-EPMC4816525 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Huang Wei W Li Qing Q Amiry-Moghaddam Mahmood M Hokama Madoka M Sardi Sylvia H SH Nagao Masashi M Warman Matthew L ML Olsen Bjorn R BR
PloS one 20160331 3
Vascular abnormalities in the eye are the leading cause of many forms of inherited and acquired human blindness. Loss-of-function mutations in the Wnt-binding co-receptor LRP5 leads to aberrant ocular vascularization and loss of vision in genetic disorders such as osteoporosis-pseudoglioma syndrome. The canonical Wnt-β-catenin pathway is known to regulate retinal vascular development. However, it is unclear what precise role LPR5 plays in this process. Here, we show that loss of LRP5 function in ...[more]