Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4816830 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhang Yong Y Li Changyin C Li Hu H Song Yipeng Y Zhao Yixia Y Zhai Lili L Wang Haixia H Zhong Ran R Tang Huiru H Zhu Dahai D
EBioMedicine 20160311
Obesity has been linked to many health problems, such as diabetes. However, there is no drug that effectively treats obesity. Here, we reveal that miR-378 transgenic mice display reduced fat mass, enhanced lipolysis, and increased energy expenditure. Notably, administering AgomiR-378 prevents and ameliorates obesity in mice. We also found that the energy deficiency seen in miR-378 transgenic mice was due to impaired glucose metabolism. This impairment was caused by an activated pyruvate-PEP futi ...[more]