Ontology highlight
ABSTRACT:
SUBMITTER: Lagerlof O
PROVIDER: S-EPMC4817221 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lagerlöf Olof O Slocomb Julia E JE Hong Ingie I Aponte Yeka Y Blackshaw Seth S Hart Gerald W GW Huganir Richard L RL
Science (New York, N.Y.) 20160301 6279
Maintaining energy homeostasis is crucial for the survival and health of organisms. The brain regulates feeding by responding to dietary factors and metabolic signals from peripheral organs. It is unclear how the brain interprets these signals. O-GlcNAc transferase (OGT) catalyzes the posttranslational modification of proteins by O-GlcNAc and is regulated by nutrient access. Here, we show that acute deletion of OGT from αCaMKII-positive neurons in adult mice caused obesity from overeating. The h ...[more]