Ontology highlight
ABSTRACT:
SUBMITTER: Felts AS
PROVIDER: S-EPMC4817271 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Felts Andrew S AS Rodriguez Alice L AL Smith Katrina A KA Engers Julie L JL Morrison Ryan D RD Byers Frank W FW Blobaum Anna L AL Locuson Charles W CW Chang Sichen S Venable Daryl F DF Niswender Colleen M CM Daniels J Scott JS Conn P Jeffrey PJ Lindsley Craig W CW Emmitte Kyle A KA
Journal of medicinal chemistry 20151111 22
Both orthosteric and allosteric antagonists of the group II metabotropic glutamate receptors (mGlus) have been used to establish a link between mGlu2/3 inhibition and a variety of CNS diseases and disorders. Though these tools typically have good selectivity for mGlu2/3 versus the remaining six members of the mGlu family, compounds that are selective for only one of the individual group II mGlus have proved elusive. Herein we report on the discovery of a potent and highly selective mGlu2 negativ ...[more]