Ontology highlight
ABSTRACT:
SUBMITTER: Ke H
PROVIDER: S-EPMC4817507 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Ke Hengning H Masoumi Katarzyna Chmielarska KC Ahlqvist Kristofer K Seckl Michael J MJ Rydell-Törmänen Kristina K Massoumi Ramin R
Scientific reports 20160401
The canonical Wnt signaling can be silenced either through β-catenin-mediated ubiquitination and degradation or through phosphorylation of Tcf and Lef by nemo-like kinase (NLK). In the present study, we generated NLK deficient animals and found that these mice become cyanotic shortly before death because of lung maturation defects. NLK-/- lungs exhibited smaller and compressed alveoli and the mesenchyme remained thick and hyperplastic. This phenotype was caused by epithelial activation of vascul ...[more]