The Mechanism of Action of Lysobactin.
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ABSTRACT:
SUBMITTER: Lee W
PROVIDER: S-EPMC4817722 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
The Mechanism of Action of Lysobactin.
Lee Wonsik W Schaefer Kaitlin K Qiao Yuan Y Srisuknimit Veerasak V Steinmetz Heinrich H Müller Rolf R Kahne Daniel D Walker Suzanne S
Journal of the American Chemical Society 20151224 1
Lysobactin, also known as katanosin B, is a potent antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis, but its molecular mechanism of action has not been established. Using enzyme inhibition assays, we show that lysobactin forms 1:1 complexes with Lipid I, Lipid II, and Lipid II(A)(WTA), substrates in the PG and wall teichoic acid (WTA) biosynthetic pathways. Therefore, lysobactin, like r ...[more]
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