Ontology highlight
ABSTRACT:
SUBMITTER: Nalivaiko K
PROVIDER: S-EPMC4817817 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Nalivaiko Kristina K Hofmann Martin M Kober Karina K Teichweyde Nadine N Krammer Peter H PH Rammensee Hans-Georg HG Grosse-Hovest Ludger L Jung Gundram G
Molecular therapy : the journal of the American Society of Gene Therapy 20151119 2
Monoclonal antibodies directed to the B-cell-specific CD20-antigen are successfully used for the treatment of lymphomas and autoimmune diseases. Here, we compare the anti-B-cell activity of three different antibodies directed to CD20: (i) a chimeric, monospecific antibody, (ii) an Fc-optimized variant thereof, and (iii) a bispecific CD20×CD95-antibody in a newly developed recombinant format, termed Fabsc. The bispecific antibody specifically triggers the CD95 death receptor on malignant, as well ...[more]