White matter lesions in FTLD: distinct phenotypes characterize GRN and C9ORF72 mutations.
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ABSTRACT:
SUBMITTER: Ameur F
PROVIDER: S-EPMC4817905 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
White matter lesions in FTLD: distinct phenotypes characterize GRN and C9ORF72 mutations.
Ameur Fatima F Colliot Olivier O Caroppo Paola P Ströer Sebastian S Dormont Didier D Brice Alexis A Azuar Carole C Dubois Bruno B Le Ber Isabelle I Bertrand Anne A
Neurology. Genetics 20160128 1
Frontotemporal lobar degeneration (FTLD) has a high frequency of genetic forms; the 2 most common are GRN (progranulin) and C9ORF72 mutations. Recently, our group reported extensive white matter (WM) lesions in 4 patients with FTLD caused by GRN mutation, in the absence of noteworthy cardiovascular risk factors,(1) in line with other studies in GRN mutation carriers.(2,3) Here we compared the characteristics of frontal WM lesions in patients with behavioral variant of FTLD (bv-FTLD) caused by GR ...[more]
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Project description:Total RNA seq on human brain tissue samples.
2020-01-21 | GSE138614 | GEO