Ontology highlight
ABSTRACT:
SUBMITTER: Yin Q
PROVIDER: S-EPMC4818026 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Yin Qian Q Yang Chengzhi C Wu Jimin J Lu Haiyan H Zheng Xiaohui X Zhang Youyi Y Lv Zhizhen Z Zheng Xiaopu X Li Zijian Z
PloS one 20160401 4
β-adrenergic receptors (β-ARs) play an important role in cardiac remodeling, which is the key pathological process in various heart diseases and leads to heart failure. However, the regulation of β-AR expression in remodeling hearts is still unclear. This study aims to clarify the possible mechanisms underlying the regulation of β1- and β2-AR expression in cardiac remodeling. The rat model of cardiac remodeling was established by subcutaneous injection of isoproterenol(ISO) at the dose of 0.25 m ...[more]