Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC4818100 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20160401 4
This study aimed to explore the effects of fucoidan from Fucus vesiculosus on concanavalin A (ConA)-induced acute liver injury in mice. Pretreatment with fucoidan protected liver function indicated by ALT, AST and histopathological changes by suppressing inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ). In addition, intrinsic and extrinsic apoptosis mediated by Bax, Bid, Bcl-2, Bcl-xL and Caspase 3, 8, and 9 were inhibited by fucoidan and the actio ...[more]