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Data from a comparative proteomic analysis of tumor-derived lung-cancer CD105(+) endothelial cells.

ABSTRACT: Increasing evidence indicates that tumor-derived endothelial cells (TECs) are more relevant for the study of tumor angiogenesis and for screening antiangiogenic drugs than normal ECs (NECs). In this data article, high-purity (>98%) primary CD105(+) NECs and TECs purified from a mouse Lewis lung carcinoma model bearing 0.5 cm tumors were identified using 2D-PAGE and Matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS). All the identified proteins were categorized functionally by Gene Ontology (GO) analysis, and gene-pathway annotated by Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, protein-protein interaction networks were also built. The proteomics and bioinformatics data presented here provide novel insights into the molecular characteristics and the early modulation of the TEC proteome in the tumor microenvironment.

SUBMITTER: Jin H

PROVIDER: S-EPMC4818351 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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Data from a comparative proteomic analysis of tumor-derived lung-cancer CD105(+) endothelial cells.

Jin Hongwei H Cheng Xiao X Pei Yihua Y Fu Jianguo J Lyu Zhi Z Peng Huifang H Yao Qin Q Jiang Yu Y Luo Lianzhong L Zhuo Huiqin H

Data in brief 20160322

Increasing evidence indicates that tumor-derived endothelial cells (TECs) are more relevant for the study of tumor angiogenesis and for screening antiangiogenic drugs than normal ECs (NECs). In this data article, high-purity (>98%) primary CD105(+) NECs and TECs purified from a mouse Lewis lung carcinoma model bearing 0.5 cm tumors were identified using 2D-PAGE and Matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS). All the identified proteins were categorized fun ...[more]

PMID: 27081670

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