Ontology highlight
ABSTRACT:
SUBMITTER: Joo JW
PROVIDER: S-EPMC4818520 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Joo Jong Wha J JW Hormozdiari Farhad F Han Buhm B Eskin Eleazar E
Genome biology 20160401
<h4>Background</h4>Multiple hypothesis testing is a major issue in genome-wide association studies (GWAS), which often analyze millions of markers. The permutation test is considered to be the gold standard in multiple testing correction as it accurately takes into account the correlation structure of the genome. Recently, the linear mixed model (LMM) has become the standard practice in GWAS, addressing issues of population structure and insufficient power. However, none of the current multiple ...[more]