Multiple testing correction in linear mixed models.

ABSTRACT:

Background

Multiple hypothesis testing is a major issue in genome-wide association studies (GWAS), which often analyze millions of markers. The permutation test is considered to be the gold standard in multiple testing correction as it accurately takes into account the correlation structure of the genome. Recently, the linear mixed model (LMM) has become the standard practice in GWAS, addressing issues of population structure and insufficient power. However, none of the current multiple testing approaches are applicable to LMM.

Results

We were able to estimate per-marker thresholds as accurately as the gold standard approach in real and simulated datasets, while reducing the time required from months to hours. We applied our approach to mouse, yeast, and human datasets to de

SUBMITTER: Joo JW 

PROVIDER: S-EPMC4818520 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature