Ontology highlight
ABSTRACT:
SUBMITTER: Conner LB
PROVIDER: S-EPMC4818681 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
The journal of pain 20151222 4
<h4>Unlabelled</h4>We hypothesized that changes in the expression of voltage-gated potassium channel (Kv) 4.3 contribute to the mechanical hyperalgesia induced by vibration injury, in a rodent model for hand-arm vibration syndrome in humans. Here we show that the exposure of the gastrocnemius muscle to vibration injury induces muscle hyperalgesia that is accompanied by a significant downregulation of Kv4.3 in affected sensory nerve fibers in dorsal root ganglia. We additionally show that the int ...[more]