Ontology highlight
ABSTRACT:
SUBMITTER: Kang Y
PROVIDER: S-EPMC4818718 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Kang Yu Y Nagaraja Archana S AS Armaiz-Pena Guillermo N GN Dorniak Piotr L PL Hu Wei W Rupaimoole Rajesha R Liu Tao T Gharpure Kshipra M KM Previs Rebecca A RA Hansen Jean M JM Rodriguez-Aguayo Cristian C Ivan Cristina C Ram Prahlad P Sehgal Vasudha V Lopez-Berestein Gabriel G Lutgendorf Susan K SK Cole Steven W SW Sood Anil K AK
Clinical cancer research : an official journal of the American Association for Cancer Research 20151118 7
<h4>Purpose</h4>Chronic adrenergic activation has been shown to associate with adverse clinical outcomes in cancer patients, but the underlying mechanisms are not well understood. The focus of the current study was to determine the functional and biologic effects of adrenergic pathways on response to chemotherapy in the context of ovarian cancer.<h4>Experimental design</h4>Increased DUSP1 production by sympathetic nervous system mediators (e.g., norepinephrine) was analyzed by real-time quantita ...[more]