Childhood onset of stiff-man syndrome.

ABSTRACT:

Importance

Reports of pediatric-onset stiff-man syndrome (SMS) are rare. This may be an underrecognized disorder in child neurology practice.

Objective

To describe patients with disorders in the SMS spectrum beginning in childhood.

Design, setting, and participants

This study was a medical record review and serological evaluation conducted at child and adult neurology clinics at the Mayo Clinic, Rochester, Minnesota. Systematic review of the literature was conducted of patients who presented from 1984-2012 with onset of symptomatic SMS occurring at age 18 years or younger.

Main outcomes and measures

Response to symptomatic and immunotherapies, patient and physician reported, including modified Rankin scale.

Results

We identified 8 patients with childhood

SUBMITTER: Clardy SL 

PROVIDER: S-EPMC4819072 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature