Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.
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ABSTRACT:
SUBMITTER: Brozovich FV
PROVIDER: S-EPMC4819215 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.
Brozovich F V FV Nicholson C J CJ Degen C V CV Gao Yuan Z YZ Aggarwal M M Morgan K G KG
Pharmacological reviews 20160401 2
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportun ...[more]
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