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A new class of Ru(II) polyazine agents with potential for photodynamic therapy.

ABSTRACT: Appending anthracene units to [(bpy)2Ru(dpp)](2+) results in Ru(II) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)](2+) and [(Anthbpy)2Ru(dpp)](2+) are the first metal-organic Ru(II) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner.

SUBMITTER: Padilla R 

PROVIDER: S-EPMC4819402 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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A new class of Ru(II) polyazine agents with potential for photodynamic therapy.

Padilla Roberto R   Rodriguez-Corrales José A JA   Donohoe Lauren E LE   Winkel Brenda S J BS   Brewer Karen J KJ  

Chemical communications (Cambridge, England) 20160201 13

Appending anthracene units to [(bpy)2Ru(dpp)](2+) results in Ru(II) agents that exhibit dynamic photoreactivity towards DNA and protein. [(Anthbpy)(bpy)Ru(dpp)](2+) and [(Anthbpy)2Ru(dpp)](2+) are the first metal-organic Ru(II) agent with dpp ligands shown to photomodify DNA in the presence or absence of oxygen, while also binding protein in an oxygen-dependent manner. ...[more]

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